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Perfect Liver Detox Support - Ingredients: Take a Closer Look

Perfect Liver Detox Support

An herbal cleansing formula, designed without synthetic nutrients, to support and maintain healthy liver function with clinically studied herbs and superfoods.

In this article we look at the ingredients in our Perfect Liver Detox Support supplement. If you are new to detox programs, you can start with our article “The Dangers of Toxins”.

Milk Thistle (Silybum marianum)

Milk Thistle (Silybum marianum) Milk thistle has been used medicinally as a “liver remedy” for almost 2,000 years. Today scientists know that the active ingredient in milk thistle, silymarin and its 3 subparts, are responsible for its liver protecting abilities.

Studies show that milk thistle regenerates injured liver cells in cases of liver toxicity. It protects the liver from toxins by not only preventing toxins from entering the liver cells, but also by removing toxins from these cells. Milk thistle increases glutathione, a potent antioxidant responsible for much of the detoxification processes in the liver.

Milk Thistle Benefits:

  • Stimulates Phase 2 liver detoxification pathways*
  • Protects the liver from toxin overload*
  • Enhances liver function*
  • Contains powerful antioxidants*
  • Reduces risk of gallstones*
  • Promotes healthy skin*
  • Promotes healthy cholesterol levels*
  • Promotes healthy blood sugar levels*

Not all Milk Thistle is Created Equal:

The Milk Thistle in Perfect Liver Detox Support is of the highest quality and has been extensively tested for contaminants and potency. It contains 80% Silymarin yielding all 6 of its isomers by HPLC : silibinin A, silibinin B, isosilibinin A, isosilibinin B, silidianin, and silicristin. Silibinin is the most active of these subparts, and is largely responsible for the benefits attributed to Silymarin. 75% of the Silymarin content of the milk thistle in this product is Silibinin (A and B).

How Much Milk Thistle is in Perfect Liver Detox Support? Perfect Liver Detox Support contains 150mg of Milk Thistle Extract per serving, which yields 120mg of Silymarin. It is recommended to take 2-3 servings per day (300-450mg of Milk Thistle and 70-200mg of Silymarin in a daily dose).

References:
World J Hepatol. 2014 Mar 27;6(3):144-9. doi: 10.4254/wjh.v6.i3.144.
Nat Prod Commun. 2013 Dec;8(12):1801-10.
Curr Drug Targets. 2013 Dec;14(14):1659-66.
Adv Exp Med Biol. 2012;771:381-95.
World J Gastroenterol. 2011 May 14;17(18):2288-301. doi: 10.3748/wjg.v17.i18.2288
Hussain SA. Silymarin as an adjunct to glibenclamide therapy improves long-term and postprandial glycemic control and body mass index in type 2 diabetes. J Med Food 2007;10:543-7.
Velussi M, Cernogoi AM, De Monte A, et al. Long-term (12 months) treatment with an antioxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. J Hepatology 1997;26:871-9.
J Agric Food Chem. 2008 Jun 11;56(11):3966-72. doi: 10.1021/jf703694u. Epub 2008 May 14.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Turmeric (Curcuma longa)

A common, yellow cooking spice known for its use in Indian curries and in yellow mustard, it has been used medicinally for 4,000 years. In Indian Ayurvedic medicine, turmeric is used to treat jaundice, chest pain, colic, and menstrual difficulties.

Today, studies demonstrate that the active constituent in turmeric, curcumin, provides powerful liver protection, antioxidant and anti-inflammatory effects. The turmeric in Perfect Liver Detox is standardized to 95% curcuminoids, the amount clinically studied to produce results.

Turmeric Benefits:

  • Stimulates Phase 2 liver detoxification pathways*
  • Protects the liver from toxic compounds*
  • Acts as a strong antioxidant and protects against free radical damage*
  • Reduces inflammation*
  • Promotes cardiovascular health*
  • Helps reduce pain and stiffness of arthritis*
  • Helps reduce stomach ulcers, excessive gas, and indigestion*
  • Suppresses micro-inflammation in the gut*
  • Supports mood and alleviates depression*

How Much Turmeric (Curcumin) is in Perfect Liver Detox Support?

Perfect Liver Detox Support contains 250mg of Turmeric per serving, and it is recommended to take 2-3 servings per day (500-750mg in a daily dose).

Why We Include this Dosage of Turmeric (Curcumin)

Curcumin is recommended at a dose of 500-1,000mg a day. A daily dose (2-3 servings) of Perfect Liver Detox Support includes 500-750mg.

Scientifically Researched Turmeric (Curcumin) Complex

The Curcumin C3 Complex in the Perfect Liver Detox Support is a registered trademark of the Sabinsa Corporation, and has been the subject of scientific investigations at a number of universities and hospitals. Curcumin C3 has three main types of curcuminoids: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. It is a patented product that research shows offers a wide range of health benefits including superb antioxidant and anti-inflammatory effects. For more information about the types of research activities and institutions where Curcumin C3 Complex has been used including a list of published studies, go to http://curcuminoids.com/.

References:
Thamlikitkul V, Bunyapraphatsara N, Dechatiwongse T, et al. Randomized double blind study of Curcuma domestica Val for dyspepsia. J Med Assoc Thai 1989;72:613-20.
Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 2005;50:2191-3.
Hishikawa N, Takahashi Y, Amakusa Y, et al. Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia. Ayu 2012;33:499-504
J Nutr Biochem. 2014 Feb;25(2):144-50. doi: 10.1016/j.jnutbio.2013.09.013. Epub 2013 Nov 6.
Curr Pharm Des. 2013;19(11):2101-13.
Int J Food Sci Nutr. 2012 Nov;63(7):832-4. doi: 10.3109/09637486.2011.607156. Epub 2012 Mar 5.
Tumour Biol. 2014 Oct 4.
Cancer Prev Res (Phila). 2014 Apr;7(4):466-74. doi: 10.1158/1940-6207.CAPR-13-0387. Epub 2014 Feb 18.
J Affect Disord. 2014 Oct;167:368-75. doi: 10.1016/j.jad.2014.06.001. Epub 2014 Jun 11.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Artichoke Leaf Extract (Cynara scolymus)

This large, thistle-like plant is one of the world’s oldest cultivated vegetables. The component responsible for its medicinal effects, cynarin, protects and regenerates the liver. This daisy family plant is similar to milk thistle in this way, and has the added benefit of strongly stimulating the gallbladder and the flow of bile. Healthy bile flow is essential for the elimination of toxins from the body.

Artichoke Leaf Benefits:

  • Stimulates the flow of bile to facilitate toxin removal*
  • Reduces indigestion, heartburn, and low stomach acidity*
  • Helps maintain healthy cholesterol levels*
  • Improves Digestive Issues*

How Much Artichoke Leaf Is in Perfect Liver Detox Support?

Perfect Liver Detox Support contains 300mg of Artichoke Leaf per serving and it is recommended to take 2-3 servings per day (600-900mg in a daily dose).

Why We Include This Dosage of Artichoke Leaf

Artichoke Leaf stimulates the flow of bile. Toxins are deposited for removal in bile. A healthy flow of bile improves detoxification. Studies show that the suggested dose of artichoke to enhance liver function is between 300 and 600 mg three times a day.

References:
Kraft K. Artichoke leaf extract–recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts.
Phytomedicine 1997;4:370-8 [review].
Kirchhoff R, Beckers C, Kirchhoff GM, et al. Increase in choleresis by means of artichoke extract. Phytomedicine 1994;1:107-15.
Rondanelli M, Giacosa A, Opizzi A, et al. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr 2013;64:7-15.
Bundy R, Walker AF, Middleton RW, et al. Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: a subset analysis. J Altern Complement Med 2004;10:667-9.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Schisandra Berry (Schisandra chinensis)

The tiny, bright red berries of the Schisandra plant are used in Traditional Chinese Medicine (TCM) as a tonic, an anti-aging herb, and to suppress cough. Schisandra berry has been historically used as an adaptogenic herb for its ability to increase resistance to stress and disease, increase energy, improve physical performance, and build strength and endurance.

Schisandra Benefits:

  • Promotes Phase 1 and Phase 2 liver detoxification pathways*
  • Promotes regeneration of liver tissue*
  • Protects the liver from toxins by promoting the production of the antioxidant glutathione*
  • Supports the immune system*
  • Promotes skin health*
  • Promotes respiratory health*
  • Supports heart health*

How Much Schisandra Berry is in Perfect Liver Detox Support?

Perfect Liver Detox Support contains 100mg of Schisandra berry per serving and it is recommended to take 2-3 servings per day (200-300mg in a daily dose).

Why We Include This Dosage of Schisandra Berry

Schisandra berry can safely be taken in doses up to eight grams a day. 100 mg per serving is a common dose used in liver formulas to offer adjunctive support in combination formulas.

References:
Planta Med. 2009 Oct;75(12):1314-8. doi: 10.1055/s-0029-1185685. Epub 2009 May 18.
Ip SP, Poon MKT, Wu SS, et al. Effect of schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity. Planta Med 1995;61:398-401.
Chang HM, But P (eds). Pharmacology and Applications of Chinese Materia Medica vol 1. Singapore: World Scientific, 1986.
Biochem Biophys Res Commun. 2012 Oct 26;427(3):547-52. doi: 10.1016/j.bbrc.2012.09.094. Epub 2012 Sep 26.
Nutr Res Pract. 2014 Jun;8(3):272-7. doi: 10.4162/nrp.2014.8.3.272. Epub 2014 May 15. Planta Med. 2000 Aug;66(6):521-5.
Immunopharmacol Immunotoxicol. 2012 Apr;34(2):292-8. doi: 10.3109/08923973.2011.602689. Epub 2011 Aug 19
J Ethnopharmacol. 2008 Jul 23;118(2):183-212. doi: 10.1016/j.jep.2008.04.020. Epub 2008 Apr 24.
Pharmacogn Mag. 2014 Jan;10(Suppl 1):S80-5. doi: 10.4103/0973-1296.127348.
Vascul Pharmacol. 2012 Sep-Oct;57(2-4):124-30. doi: 10.1016/j.vph.2012.06.002. Epub 2012 Jun 20.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Broccoli Sprout Powder

Broccoli is a well-known cruciferous vegetable superfood, and the sprouts are 20–150 times more nutrient dense than the full grown plant. Research demonstrates that sulforaphane from broccoli has many profound health benefits, above and beyond helping the body with detoxification.

Sulforaphane speeds up the body’s ability to detoxify pollutants. Recent research from John’s Hopkins Bloomberg School of Public Health demonstrates that participants in the Jiangsu Province of China who drank a mixture containing dissolved freeze dried broccoli sprout powder increased the excretion rate of two carcinogenic air pollutants, benzene (by 61%) and acrolein (by 23%). Research suggests that sulforaphane in broccoli sprouts may elevate the capacity of cells to adapt and survive a broad range of environmental toxins.

Broccoli Sprout Powder Benefits:

  • Stimulates Phase 2 liver detoxification pathways*
  • Enhances the body’s ability to detoxify pollutants*
  • Increases glutathione, a natural antioxidant*

How Much Broccoli Sprout Powder is in Perfect Liver Detox Support?

Perfect Liver Detox Support contains 400mcg of Sulfurophane (the active constituent of broccoli sprouts) per serving and it is recommended to take 2-3 servings per day (800-1200mcg of Sulfurophane in a daily dose).

Why We Include This Dosage of Sulfurophane

Taking between 100-300mg of broccoli sprouts powder (yielding 800-1200mcg of Sulfurophane) per day has been scientifically shown to aid in both Phase 1 and Phase 2 detoxification pathways. Perfect Liver Detox Support provides the necessary 100-300mg of broccoli sprouts powder in a daily dose (2-3 servings).

References:
“Rapid and Sustainable Detoxification of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China” was written by Patricia A. Egner; Jian Guo Chen; Adam T Zarth; Derek Ng; Jinbing Wang; Kevin H Kensler; Lisa P Jacobson; Alvaro Munoz; Jamie L Johnson; John D Groopman; Jed W. Fahey; Paul Talalay; Jian Zhu; Tao-Yang Chen; Geng-Sun Qian; Steven G. Carmella; Stephen S. Hecht; and Thomas W. Kensler.
Proc Natl Acad Sci U S A. Sep 16, 1997; 94(19): 10367–10372.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Cilantro (Coriandrum sativum)

The leafy green herb, Cilantro, is a uniquely flavored cooking herb and also a powerful heavy metal chelator. Cilantro has been shown to protect against lead exposure, and to increase the release of mercury, lead, and aluminum from the body.

Recent studies also show that cilantro leaves may have a positive effect on memory and cholesterol. Cilantro leaf has strong anti-inflammatory and antioxidant properties.

Cilantro Benefits:

  • Enhances the elimination of heavy metals*
  • Promotes healthy cholesterol*
  • Provides antioxidant activity*
  • Reduces inflammation*

How Much Cilantro Is in Perfect Liver Detox Support?

The Perfect Liver Detox Support contains 125mg of Cilantro per serving and it is recommended to take 2-3 servings per day (250-375mg of Cilantro in a daily dose).

Why We Include This Dosage of Cilantro

When used at a dose of 250-1000 mg, the combination of Chlorella and Cilantro work together to effectively bind heavy metals in foods and in the gastrointestinal tract. A daily dose of Perfect Liver Detox Support (2-3 servings) provides 650-915mg of Chlorella and Cilantro.

Chlorella and Cilantro (C&C) aid in removing toxins that are neutralized in the liver and delivered to the GI tract through the bile. In the GI tract, C&C help to further bind the toxins in the colon for elimination through the stool. This binding activity helps to prevent the reabsorption of the toxins back into the bloodstream.

References:
Biol Trace Elem Res. 2010 Sep;136(3):337-54. doi: 10.1007/s12011-009-8553-0. Epub 2009 Nov 10.
Acupunct Electrother Res. 1995 Aug-Dec;20(3-4):195-229.
J Ethnopharmacol. 2001 Oct;77(2-3):203-8.
J Sci Food Agric. 2011 Jan 15;91(1):186-92. doi: 10.1002/jsfa.4171. Epub 2010 Sep 17.
J Sci Food Agric. 2010 Aug 30;90(11):1846-54. doi: 10.1002/jsfa.4023.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Chlorella (Chlorella vulgaris)

Chlorella is a tiny, one-celled, green algae containing chlorophyll, carotenoids, amino acids, fibers, and fatty acids. The outer cell wall of these micro-algae is tough, but valuable. Once broken to improve digestibility, it binds with heavy metals such as cadmium and lead, pesticides and carcinogens such as PCBs and carries them safely out of the body. The cell wall of chlorella also contains complex polysaccharides that enhance immune function and improve heart health.

Chlorella Benefits:

  • Enhances the elimination of heavy metals*
  • Protects the liver*
  • Enhances immune function*
  • Promotes healthy arterial flow*
  • Helps maintain healthy cholesterol levels*

How Much Chlorella is in Perfect Liver Detox Support?

Perfect Liver Detox Support contains 200mg of Chlorella per serving, and it is recommended to take 2-3 servings per day (400-600mg of Chlorella in a daily dose).

Why We Include this Dosage of Chlorella

When used at a dose of 250-1000 mg, the combination of Chlorella and Cilantro work together to effectively bind heavy metals in foods and in the gastrointestinal tract. A daily dose of Perfect Liver Detox Support (2-3 servings) provides 650-915mg of Chlorella and Cilantro.

Chlorella and Cilantro (C&C) aid in removing toxins that are neutralized in the liver and delivered to the GI tract through the bile. In the GI tract, C&C help to further bind the toxins in the colon for elimination through the stool. This binding activity helps to prevent the reabsorption of the toxins back into the bloodstream.

References:
Nutr J. 2014 Jun 11;13:57. doi: 10.1186/1475-2891-13-57.
J Med Food. 2008 Sep;11(3):479-85. doi: 10.1089/jmf.2007.0075.
Hepatogastroenterology. 2012 Oct;59(119):2099-2103. doi: 10.5754/hge10860
J Reticuloendothel Soc. 1973 Aug;14(2):192-208.
Chemosphere. 2005 Dec;61(9):1244-55. Epub 2005 Jun 27.
J Clin Biochem Nutr. 2013 Nov;53(3):166-9. doi: 10.3164/jcbn.13-51. Epub 2013 Oct 3
Altern Ther Health Med. 2001 May-Jun;7(3):79-91.
J Sci Food Agric. 2010 Jul;90(9):1551-6. doi: 10.1002/jsfa.3989.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

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